This is a case presented Oct 7, 2011.
It comes from the Brigham and Women's Kidney Pathology Conference by Dr. Ibrahim Batal and Dr. Vanessa Bijol.
The correct answer is A. It is quite coincidental that I happened to be moderating the ASN CPC and a case of adenovirus nephropathy was also presented! There is a beautiful discussion of this topic in JASN, as well a description of a case in AJKD in 2003. It is also discussed on the Nephron Power blog. The biopsy often shows a granulomatous interstitial nephritis, tubular necrosis, and ground glass-like intranuclear viral inclusion bodies in tubular cells caused by an adenovirus (ADV) infection.
Brief Case Presentation: The patient's biopsy was sent to the Brigham by a pathology colleague from Colombia for special staining. A 50 year-old male status post-kidney transplantation suddenly develops septic shock with rapid renal dysfunction (serum creatinine is 6 mg/dL).
What is the diagnosis on the renal biopsy?
A. Adenovirus nephropathy
B. BK virus nephropathy
C. CMV virus nephropathy
D. E-coli pyelonephritis
E. Acute cellular rejection
Additional slides from Dr. Batal:
It comes from the Brigham and Women's Kidney Pathology Conference by Dr. Ibrahim Batal and Dr. Vanessa Bijol.
The correct answer is A. It is quite coincidental that I happened to be moderating the ASN CPC and a case of adenovirus nephropathy was also presented! There is a beautiful discussion of this topic in JASN, as well a description of a case in AJKD in 2003. It is also discussed on the Nephron Power blog. The biopsy often shows a granulomatous interstitial nephritis, tubular necrosis, and ground glass-like intranuclear viral inclusion bodies in tubular cells caused by an adenovirus (ADV) infection.
Brief Case Presentation: The patient's biopsy was sent to the Brigham by a pathology colleague from Colombia for special staining. A 50 year-old male status post-kidney transplantation suddenly develops septic shock with rapid renal dysfunction (serum creatinine is 6 mg/dL).
What is the diagnosis on the renal biopsy?
A. Adenovirus nephropathy
B. BK virus nephropathy
C. CMV virus nephropathy
D. E-coli pyelonephritis
E. Acute cellular rejection
Additional slides from Dr. Batal:
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