A 58-year-old
male in the intensive care unit is intubated for respiratory failure due to
severe pneumonia and is paralyzed with vecuronium and sedated with lorazepam. A
renal consult is called because of the laboratory finding of metabolic
acidosis.
Laboratory
Studies
Serum sodium 136
mEq/L
Serum potassium
4.0 mEq/L
Serum chloride
101 mEq/L
Serum
bicarbonate 14 mEq/L
Blood urea
nitrogen 13 mg/dL
Serum creatinine
0.8 mg/dL
Serum glucose
108 mg/dL
Serum lactate 10
mmol/L
Serum osmolality
299 mOsm/kg
Arterial blood
studies on 60% O2:
pH 7.37
PCO2 20 mm Hg
The most
appropriate next step in the management of this patient is:
A. Dopamine
B. Dobutamine
C. Abdominal
computed tomography
D. Discontinue
lorazepam
E. None of the
above
Nice post about MBA i like it.
ReplyDeleteThe patient has AGAP metabolic acidosis with positive osmolal GAP. In this setting, most likely from propylene glycol toxicity in patient receiving high-dose lorazepam.
ReplyDeleteI would discontinue Lorazepam.