This is a quote from a fantastic article by Danovitch and Al-Mousawi -available open access: “At least ten percent of the organs transplanted globally each year are
obtained through trafficking [Lancet 369, 1901 (2007)] - in some
countries nearly all kidneys donated by the local population were for paying
foreign recipients”
Recall that the “The Declaration of Istanbulon Organ Trafficking and Transplant Tourism” was
adopted at an international meeting held in 2008. The Declaration provided a
set of principles and a series of proposals “to improve the ethics and expand
the benefits of the international organ transplantation endeavor.”
In a very nice article on transplant tourism from New Zealand the issue
of transplant tourism is re-visited.
Here is a quote from the article: “Sadly the number
of people who need organs is growing. The transplant waitlists are getting
longer, five years for a kidney, and that is if you are lucky enough to even
get one. The supply of organs from both living and deceased donors is getting
shorter. With this in mind, it is understandable why people are
turning to illegally purchase organs from overseas. However, there are also
many reports of deaths of patients who have gone abroad for commercial
transplants.”
The article goes on and cites Rachel Walsh who is
researching into this issue: “there were three types of trafficking. The first
type was where a trafficker forces or coerces a victim to give up one or more
of their organs. The second instance was where a victim’s organ was removed
without their knowledge. The final type of trafficking was where victims were
not paid the amount agreed upon for the sale of their organs. Organ trafficking
victims are usually poor, homeless, or illiterate, therefore vulnerable to
traffickers. There are numerous people involved in organ trafficking, including
hospitals, doctors, middlemen, organ banks and transporters. Kidneys are most
sought after. With trafficking, anything that can be removed can be sold on,
regardless of the age or lack of consent of the victim.’’
Here is a quote from the Danovitch article:
“Promotion of such self-sufficiency is at the core of any attempt to
resolve the problem of organ donor shortages and to prevent organ trafficking
and transplant tourism; however, achieving this goal requires a favorable
legislative framework. In this regard, the complementary goals of the
Declaration and the WHO Guiding Principles are invaluable. Development of a
critical pathway to evaluate the national potential for deceased donation was
endorsed by the 3rd WHO Global Consultation on Organ Donation and
Transplantation held in Madrid, Spain, in 2010. The purpose of this pathway is
to facilitate deceased donation according to international norms, particularly
in countries where deceased donation is currently absent or rudimentary.”
The issue is this: we all agree that organ trafficking is
reprehensible and unethical, however, the flip side to this is that policy
makers have been rather slow in legislating cadaveric or deceased donors as a source of kidneys. And, this slowness is now a major factor in driving continued organ trafficking.
Take for example, the UAE, it is now starting to write laws in this area. Even among countries where legislation is in place, government’s have been slow in implementing deceased donor programs. In India, a law is in place but only sparsely implemented. Policy makers need to speed up in both enacting and implementing laws banning organ trafficking. Lip service just won't cut it.
Take for example, the UAE, it is now starting to write laws in this area. Even among countries where legislation is in place, government’s have been slow in implementing deceased donor programs. In India, a law is in place but only sparsely implemented. Policy makers need to speed up in both enacting and implementing laws banning organ trafficking. Lip service just won't cut it.

Thank you always for an interesting blog!
ReplyDeleteOrgan trafficking and transplant tourism are topics that, like those of human trafficking, will probably never be completely eradicated.
There is an interesting example on how the kidney problem was tackled in Iran presented by Dr. Hippen in the following article.
http://www.cato.org/publications/policy-analysis/organ-sales-moral-travails-lessons-living-kidney-vendor-program-iran
Whether one agrees with this strategy or not it is an interesting study in the human psyche.
All the best
CPI-613 orphan drugs in the treatment of acute myeloid leukemia
ReplyDeleteIt is reported, Cornerstone Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted the CPI-613 orphan drug status, CPI-613 is the company's main product candidate for the treatment of acute myeloid leukemia (AML).
"CPI-613 orphan drug status significantly enhance its value proposition, provide further support and promote clinical measures only a very few treatment options AML patients hope of Cornerstone CEO Dr. RobertShorr said.
CPI-613 can induce tumor-specific inhibition of the pyruvate dehydrogenase (PDH), PDH is a key mitochondrial enzyme associated with the metabolism of cancer cells. The PDH functions destruction can lead to devastating destruction of the tumor cell mitochondrial metabolism. Thus, tumor cells will be a lack of energy and biosynthetic intermediates, ultimately leading to cell death.
A blood system cancers Phase I trial, as well as solid tumors Phase I and Phase I / II clinical trials are evaluating CPI-613.
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